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KMID : 0606920200280050397
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Biomolecules & Therapeutics
2020 Volume.28 No. 5 p.397 ~ p.404
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Diallyl Biphenyl-Type Neolignans Have a Pharmacophore of PPARα/γ Dual Modulators
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Han Yujia
Liu Jingjing
Ahn Sung-Jin
An Seung-Chan
Ko Hye-Jin
Shin Jea-Young
Jin Sun-Hee
Ki Min-Won
Lee So-Hun
Lee Kang-Hyuk
Shin Song-Seok
Choi Won-Jun
Noh Min-Soo
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Abstract
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Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adiponectin- secretion promoting compounds in the adipogenic differentiation model of human bone marrow mesenchymal stem cells (hBM-MSCs). In a target identification study, magnolol, honokiol, and 4-O-methylhonokiol were elucidated as PPARα and PPARγ dual modulators. Diallyl biphenyl-type neolignans affected the transcription of lipid metabolism-associated genes in a different way compared to those of specific PPAR ligands. The diallyl biphenyl-type neolignan structure provides a novel pharmacophore of PPARα/γ dual modulators, which may have unique therapeutic potentials in diverse metabolic diseases.
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KEYWORD
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Diallyl biphenyl-type neolignans, Adiponectin, Human bone marrow mesenchymal stem cells, Peroxisome proliferatoractivated receptor α/γ
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